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接受高效抗逆转录病毒疗法（HAART）的HIV感染男性未能恢复Vγ2-Jγ1.2基因库。

Failure to restore the Vgamma2-Jgamma1.2 repertoire in HIV-infected men receiving highly active antiretroviral therapy (HAART).

作者信息

Hebbeler Andrew M, Propp Nadia, Cairo Cristiana, Li Haishan, Cummings Jean Saville, Jacobson Lisa P, Margolick Joseph B, Pauza C David

机构信息

Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, USA.

出版信息

Clin Immunol. 2008 Sep;128(3):349-57. doi: 10.1016/j.clim.2008.04.008. Epub 2008 Jul 7.

DOI:10.1016/j.clim.2008.04.008
PMID:18606571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2603626/
Abstract

Gammadelta (gammadelta) T cells expressing the Vgamma2-Jgamma1.2Vdelta2 (Vgamma9-JPVdelta2, alternate nomenclature) T cell receptor (TCR) constitute the major peripheral blood population of gammadelta T cells in adult humans and are specifically depleted during human immunodeficiency virus (HIV) disease. Vgamma2-Jgamma1.2Vdelta2 T cells provide a convenient model for assessing the impact of antiretroviral therapy on cell populations that are not susceptible to direct infection because they do not express CD4 and depletion occurs by indirect mechanisms. We obtained longitudinal PBMC samples from 16 HIV-infected individuals who enrolled in the Multicenter AIDS Cohort Study (MACS) and were starting highly active antiretroviral therapy (HAART). Vgamma2-Jgamma1.2Vdelta2 T cells were depleted in these individuals as a result of HIV infection. Despite evidence for clinical benefits of HAART, the Vgamma2-Jgamma1.2Vdelta2 T cell repertoire did not recover after HAART initiation irrespective of treatment duration. These studies highlight important defects among cell subsets lost due to indirect effects of HIV.

摘要

表达Vγ2-Jγ1.2Vδ2（Vγ9-JPVδ2，替代命名法）T细胞受体（TCR）的γδ（γδ）T细胞构成了成年人类外周血中γδT细胞的主要群体，并且在人类免疫缺陷病毒（HIV）疾病期间会特异性减少。Vγ2-Jγ1.2Vδ2 T细胞为评估抗逆转录病毒疗法对不易直接感染的细胞群体的影响提供了一个便利的模型，因为它们不表达CD4，且细胞减少是通过间接机制发生的。我们从16名参与多中心艾滋病队列研究（MACS）并开始接受高效抗逆转录病毒疗法（HAART）的HIV感染个体中获取了纵向外周血单核细胞（PBMC）样本。由于HIV感染，这些个体中的Vγ2-Jγ1.2Vδ2 T细胞减少。尽管有证据表明HAART具有临床益处，但无论治疗持续时间如何，在开始HAART后Vγ2-Jγ1.2Vδ2 T细胞库都没有恢复。这些研究突出了因HIV间接作用而丢失的细胞亚群中的重要缺陷。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82af/2603626/95f0f096999e/nihms67903f1.jpg

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