Wolf David S, Singer Harvey S
Department of Neurology, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-1000, USA.
Curr Opin Neurol. 2008 Aug;21(4):491-6. doi: 10.1097/WCO.0b013e328307bf1c.
Pediatric movement disorders the represent a broad range of disorders, the majority of which are intermittent and hyperkinetic. The goal of this review is to discuss recent findings in several under-recognized conditions (motor stereotypy disorder, restless legs syndrome, and infantile masturbation) as well as the area of autoimmune movement disorders [Sydenham's chorea and PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection)].
Advances to be discussed include clarification of symptoms, diagnostic clues, epidemiology, pathogenesis, and treatment.
Significant progress has been made in the study of several paroxysmal movement disorders. Motor stereotypies can occur in typical children and persist over time. Infantile masturbation is often misdiagnosed for seizures or dystonia. Restless leg syndrome is a relatively common problem in children and established criteria are available. Advances have been made in the hallmark autoimmune disorder Sydenham's chorea, but PANDAS remains controversial.
儿童运动障碍涵盖多种疾病,其中大多数为间歇性和多动性疾病。本综述的目的是讨论几种未得到充分认识的疾病(运动刻板障碍、不安腿综合征和小儿自慰)以及自身免疫性运动障碍领域[ Sydenham舞蹈病和PANDAS(与链球菌感染相关的小儿自身免疫性神经精神疾病)]的最新研究结果。
将讨论的进展包括症状的明确、诊断线索、流行病学、发病机制和治疗。
在几种阵发性运动障碍的研究中取得了重大进展。运动刻板行为可发生在正常儿童中并随时间持续存在。小儿自慰常被误诊为癫痫或肌张力障碍。不安腿综合征在儿童中是一个相对常见的问题,且已有既定标准。在典型的自身免疫性疾病Sydenham舞蹈病方面取得了进展,但PANDAS仍存在争议。