Gambino Antonio, Torregrossa Gianluca, Cozzi Emanuele, Angelini Annalisa, De Silvestro Giustina, Cerutti Alessia, Feltrin Giuseppe, Toscano Giuseppe, d'Agostino Chiara, Zanella Fabio, Thiene Gaetano, Gerosa Gino
Department of Cardiological, Thoracic and Vascular Science, Cardiac Surgery Unit, Italy.
J Cardiovasc Med (Hagerstown). 2008 Aug;9(8):854-7. doi: 10.2459/JCM.0b013e3282f64233.
Due to the shortage of organ donors, heart transplantation cannot be offered to many infants with end-stage heart failure; this issue leads to mortality rates of 30-50% in patients in the paediatric age group awaiting operation. ABO-incompatible heart transplantation has been performed safely with no particular or invasive preparatory procedures other than plasma exchange during cardiopulmonary bypass for removing preformed antibodies, with no reports of hyperacute rejection. We report our first clinical experience of heart transplantation on a 2-month-old-infant (blood group O), diagnosed with intracardiac tumour, in which the donor was a 19-day-old newborn of blood group A. Sharing the know-how about ABO-incompatible heart transplantation in newborns and infants awaiting transplantation will help in decreasing mortality among this group of patients.
由于器官捐献者短缺，许多终末期心力衰竭的婴儿无法接受心脏移植；这个问题导致等待手术的儿科年龄组患者的死亡率为30%至50%。除了在体外循环期间进行血浆置换以去除预先形成的抗体外，ABO血型不相容的心脏移植已安全实施，无需特殊或侵入性的准备程序，也没有超急性排斥反应的报告。我们报告了我们对一名2个月大婴儿（O血型）进行心脏移植的首例临床经验，该婴儿被诊断患有心脏肿瘤，供体是一名19天大的A型血新生儿。分享关于等待移植的新生儿和婴儿ABO血型不相容心脏移植的专业知识将有助于降低这组患者的死亡率。
