Unibioscreen SA, Avenue Joseph Wybran, B-1070 Brussels, Belgium.
Transl Oncol. 2008 Mar;1(1):1-13. doi: 10.1593/tlo.08100.
This review covers the isolation, total synthesis, biologic activity, and more particularly the in vitro and in vivo antitumor activities of naturally occurring isocarbostyril alkaloids from the Amaryllidaceae family. Starting from these natural products, new derivatives have been synthesized to explore structure-activity relationships within the chemical class and to obtain potential candidates for preclinical development. This approach appears to be capable of providing novel promising anticancer agents.
这篇综述涵盖了来自石蒜科的天然异卡波林生物碱的分离、全合成、生物活性,特别是体外和体内抗肿瘤活性。从这些天然产物出发,合成了新的衍生物,以探索该类化合物的构效关系,并获得潜在的临床前开发候选物。这种方法似乎能够提供有前途的新型抗癌药物。