Neuber H, Lippold A, Hundeiker M
Fachklinik Hornheide, Westfälischen Wilhelms-Universität Münster.
Hautarzt. 1991 Apr;42(4):220-2.
Of the 3574 malignant melanomas treated in Hornheide between December 1981 and August 1990 (not including preinvasive cases) 97 were not immediately recognized. These tumours did not look like melanomas. In 72% they were smaller than 10 mm in diameter, and in 20%, smaller than 5 mm. Clark's so often quoted "pencil rule" should no longer be used as an aid to exclusion of invasive melanoma. Localization of the unrecognized melanomas was on the head and neck in 22% of cases. In 37%, the patients were under the age of 40 years. No less than 25% of the patients had multiple melanomas. Many of these melanomas. Many of these melanomas were thin tumours (less than 0.75 mm in 55% and less than 1.5 mm in 77%). This explains why more than 50% of the lesions are described as "macules". The most common incorrect diagnoses were dysplastic naevi (44%) and common (23%) naevi. The most important anamnestic criteria are the patients' own statements about changes in size, colour and shape. These "dynamic" elements must be more carefully observed and documented during process of the clinical diagnosis.
1981年12月至1990年8月期间,在霍恩海德接受治疗的3574例恶性黑色素瘤(不包括原位癌病例)中,有97例未被立即识别。这些肿瘤看起来不像黑色素瘤。其中72%的肿瘤直径小于10毫米,20%的肿瘤直径小于5毫米。克拉克经常被引用的“铅笔法则”不应再被用作排除浸润性黑色素瘤的辅助手段。未被识别的黑色素瘤在22%的病例中位于头颈部。37%的患者年龄在40岁以下。不少于25%的患者患有多发性黑色素瘤。这些黑色素瘤中有许多是薄肿瘤(55%的肿瘤厚度小于0.75毫米,77%的肿瘤厚度小于1.5毫米)。这就解释了为什么超过50%的病变被描述为“斑疹”。最常见的误诊是发育异常痣(44%)和普通痣(23%)。最重要的既往史标准是患者自己关于大小、颜色和形状变化的陈述。在临床诊断过程中,必须更仔细地观察和记录这些“动态”因素。