Gartmann H, Pullmann H
Z Hautkr. 1981 Apr 15;56(8):509-34.
It is sometimes difficult to recognize precursors and early forms of malignant melanoma, even in histologic sections. Atypic melanocyte hyperplasia (AMH) occurs in the epidermal part of several benign pigment cell tumours and often evoke the suspicion of beginning malignancy. Probably there are some potentials for malignant transformation in AMH. Severe atypical melanocytic hyperplasia (SMH) corresponds to the concept of "early malignancy" in the meaning of McGovern. Severe melanocytic dysplasia (SMD) in the meaning of Clark et al. stands for an intraepidermal malignant melanoma (melanoma in situ). SMD occurs in SSM and in lentigo maligna. Sometimes it is impossible to assign it to a special type of melanoma. The importance to recognize histologically the differing behaviour of proliferating melanocytes within the epidermis for diagnosis of early malignant melanoma is accentuated.
即使在组织学切片中，有时也很难识别恶性黑色素瘤的前驱病变和早期形式。非典型黑素细胞增生（AMH）发生于几种良性色素细胞肿瘤的表皮部分，常引发恶性病变起始的怀疑。AMH可能存在一些恶性转化的潜能。重度非典型黑素细胞增生（SMH）与麦戈文所指的“早期恶性肿瘤”概念相对应。克拉克等人所指的重度黑素细胞发育异常（SMD）代表表皮内恶性黑色素瘤（原位黑色素瘤）。SMD见于浅表扩散性黑色素瘤和恶性雀斑样痣。有时无法将其归为某一特定类型的黑色素瘤。强调了在组织学上识别表皮内增殖黑素细胞的不同行为对于早期恶性黑色素瘤诊断的重要性。
