Postema Rolf J, Kingma Charlotte M, Wit Hero P, Albers Frans W J, Van Der Laan Bernard F A M
Department of Otorhinolaryngology, University Medical Center Groningen, Groningen, The Netherlands.
Acta Otolaryngol. 2008 Aug;128(8):876-80. doi: 10.1080/00016480701762458.
Intratympanic application of gentamicin is a relatively safe and efficient treatment for the reduction of complaints of vertigo attacks associated with Menière's disease. The treatment also reduces the severity of the perceived aural fullness.
To investigate the effectiveness of intratympanic gentamicin treatment in patients with unilateral Menière's disease.
In a prospective, double-blind, randomized, placebo-controlled clinical trial subjects scored vertigo complaints, aural fullness and tinnitus, before, during and up to 1 year after treatment. Hearing loss was monitored with pure tone audiometry.
Gentamicin treatment resulted in a significant reduction of the score for vertigo complaints and the score for perceived aural fullness. A small increase in hearing loss (average 8 dB) was measured in the gentamicin group.
鼓室内应用庆大霉素是一种相对安全有效的治疗方法，可减少梅尼埃病相关眩晕发作的主诉。该治疗还可减轻耳胀满感的严重程度。
研究鼓室内注射庆大霉素治疗单侧梅尼埃病患者的有效性。
在一项前瞻性、双盲、随机、安慰剂对照临床试验中，受试者在治疗前、治疗期间及治疗后长达1年的时间里，对眩晕主诉、耳胀满感和耳鸣进行评分。采用纯音听力计监测听力损失情况。
庆大霉素治疗使眩晕主诉评分和耳胀满感评分显著降低。庆大霉素组的听力损失有小幅增加（平均8 dB）。
