Brüning H, Christophers E
Hautklinik der Christian-Albrechts-Universität Kiel.
Hautarzt. 1991 Apr;42(4):227-32.
Six patients suffering from solitary cryofibrinogenaemia are described. In one patient idiopathic cryofibrinogenaemia was present, while the others showed secondary cryofibrinogenaemia associated with borrelia infection, chronic venous insufficiency with pulmonary embolism, primary biliary cirrhosis, diabetes mellitus or von-Willebrand syndrome. Subcutaneous injections of the thrombin-like snake poison batroxobin/ancrod were administered over a period of several weeks. Five patients experienced almost complete remission of their symptoms, especially of pain following cold exposure. In one patient partial relief was achieved. Overall we found a 75% reduction of symptoms. When blood fibrinogen levels are carefully monitored this therapy is an efficient and safe form of treatment for cryofibrinogenaemia.
本文描述了6例患有孤立性冷纤维蛋白原血症的患者。其中1例为特发性冷纤维蛋白原血症，其他患者表现为与莱姆病感染、伴有肺栓塞的慢性静脉功能不全、原发性胆汁性肝硬化、糖尿病或血管性血友病综合征相关的继发性冷纤维蛋白原血症。在数周时间内给予皮下注射类凝血酶蛇毒巴曲酶/安克洛酶。5例患者的症状几乎完全缓解，尤其是冷暴露后的疼痛。1例患者症状部分缓解。总体而言，我们发现症状减轻了75%。当仔细监测血液纤维蛋白原水平时，这种疗法是治疗冷纤维蛋白原血症的一种有效且安全的方式。
