Kakigi Akinobu, Nishimura Masahiko, Takeda Taizo, Okada Teruhiko, Murata Yoriko, Ogawa Yasuhiro
Department of Otolaryngology, Kochi Medical School, Kochi, Japan.
Acta Otolaryngol. 2008 Aug;128(8):841-5. doi: 10.1080/00016480701769776.
The concentration of gadolinium (Gd) used clinically showed no remarkable effects on the stria vascularis; however, a higher concentration had adverse effects. The concentration of Gd must be borne in mind when injecting Gd into the tympanic cavity.
Endolymphatic hydrops has been visualized using high resolution MRI with the intratympanic administration of Gd in patients with Meniere's disease. We attempted to investigate the effects of Gd on the stria vascularis.
Gd hydrate diluted eightfold with saline or non-diluted Gd or saline was injected into the tympanic cavity of guinea pigs. To investigate the effects of Gd on the stria vascularis, we measured endocochlear DC potential (EP) and observed the stria vascularis using transmission electron microscopy.
Intratympanic injections of Gd hydrate diluted eightfold with saline (1/8 Gd) and saline did not cause apparent changes in the EP. Moreover, the amplitude of the EP decreased significantly 60 min after non-diluted Gd was injected. Transmission electron micrographs of the stria vascularis revealed no significant morphological difference between the ears injected with 1/8 Gd and those injected with saline. There was significant morphological change in the ear injected with non-diluted Gd. The intercellular spaces were markedly enlarged.
临床使用的钆（Gd）浓度对血管纹无显著影响；然而，较高浓度则有不良影响。向鼓室注射钆时必须牢记钆的浓度。
梅尼埃病患者经鼓室内注射钆后，已通过高分辨率MRI观察到内淋巴积水情况。我们试图研究钆对血管纹的影响。
将用生理盐水稀释8倍的水合钆、未稀释的钆或生理盐水注入豚鼠鼓室。为研究钆对血管纹的影响，我们测量了蜗内直流电位（EP），并使用透射电子显微镜观察血管纹。
向鼓室内注射用生理盐水稀释8倍的水合钆（1/8 Gd）和生理盐水后，EP未出现明显变化。此外，注射未稀释的钆60分钟后，EP幅度显著下降。血管纹的透射电子显微镜图像显示，注射1/8 Gd的耳朵与注射生理盐水的耳朵之间在形态上无显著差异。注射未稀释钆的耳朵出现了显著的形态变化。细胞间隙明显增大。
