Walter Garry, DeLaroche Amy, Soh Nerissa, Hunt Glenn, Cleary Michelle, Malhi Gin, Lambert Tim, Correll Christoph, Rey Joseph
Discipline of Psychological Medicine, University of Sydney, Australia.
Australas Psychiatry. 2008 Aug;16(4):253-62. doi: 10.1080/10398560801958549.
The aim of this study was to ascertain the experiences, views and monitoring practices of Australian child psychiatrists regarding the metabolic and other side effects of second-generation antipsychotics (SGAs).
A 19-item questionnaire was posted to all members of the RANZCP Faculty of Child and Adolescent Psychiatry living in Australia.
Of the 290 eligible members of the Faculty of Child and Adolescent Psychiatry, 126 (43%) returned a useable survey. SGAs are commonly prescribed for a range of disorders. The majority of respondents expressed a high level of concern regarding weight gain and other metabolic side effects. Weight gain was the most frequently observed and monitored side effect in clinical practice. Other side effects were observed and monitored to a variable extent. Notably, monitoring practices did not parallel psychiatrists' reported level of concern or knowledge regarding weight gain and metabolic side effects,nor coincide with published recommendations.
Further research is required into the use, efficacy, side effects and monitoring of SGAs in children and adolescents, and there is a need to ensure that monitoring guidelines are implemented in clinical practice. This need is heightened by the likelihood that our data on clinicians' practice, which is based on their perceptions, may overestimate what actually occurs.
本研究旨在确定澳大利亚儿童精神科医生在第二代抗精神病药物(SGA)的代谢及其他副作用方面的经验、观点和监测实践。
向居住在澳大利亚的皇家澳大利亚和新西兰精神科医学院儿童与青少年精神医学系的所有成员发放了一份包含19个条目的问卷。
在儿童与青少年精神医学系的290名符合条件的成员中,126人(43%)返回了有效调查问卷。SGA常用于治疗一系列疾病。大多数受访者对体重增加和其他代谢副作用表示高度关注。体重增加是临床实践中最常观察和监测的副作用。其他副作用的观察和监测程度各不相同。值得注意的是,监测实践与精神科医生报告的对体重增加和代谢副作用的关注程度或了解情况并不一致,也与已发表的建议不符。
需要进一步研究SGA在儿童和青少年中的使用、疗效、副作用及监测情况,并且有必要确保在临床实践中实施监测指南。鉴于我们基于临床医生认知得出的关于其实践的数据可能高估了实际发生的情况,这种需求更加迫切。