Bawden Harry N, Salisbury Sonia, Eskes Gail, Morehouse Rachel
Department of Psychology, IWK Health Centre, Halifax, Nova Scotia, Canada.
J Clin Exp Neuropsychol. 2009 Jan;31(1):140-4. doi: 10.1080/13803390802064599. Epub 2008 Jun 12.
The neuropsychological functioning of patients who had undergone surgical removal of craniopharyngiomas was compared to that of an endocrine control group composed of patients with nontumor hypopituitarism, an obese control group, and a normal control group. Neuropsychological assessments consisting of measures of intelligence, memory, attention, and executive functioning were carried out. The craniopharyngioma group had lower Performance IQ than did the normal control group, but their Performance IQ was comparable to that of the hypopituitarism and obese control groups. The craniopharyngioma patients did not differ in Verbal or Full Scale IQs from the remaining groups. There were no group differences on measures of verbal or nonverbal memory, ability to sustain attention, or executive functioning including measures of verbal or figural fluency, nonverbal problem solving, ability to copy a complex geometric figure, and visual motor and visual sequencing skills. The group mean scores on the measures of intelligence and neuropsychological abilities for the craniopharyngioma patients were in the low-average to average range. While craniopharyngioma patients can have significant morbidity including endocrine and visual deficits as well as obesity resulting from hyperphagia, neuropsychological deficits are not always present. Their neuropsychological outcome is more benign than some previous studies have suggested.
将接受颅咽管瘤手术切除的患者的神经心理功能与由非肿瘤性垂体功能减退患者组成的内分泌对照组、肥胖对照组和正常对照组进行了比较。进行了包括智力、记忆、注意力和执行功能测量在内的神经心理评估。颅咽管瘤组的操作智商低于正常对照组，但其操作智商与垂体功能减退和肥胖对照组相当。颅咽管瘤患者在言语智商或全量表智商方面与其余组没有差异。在言语或非言语记忆、持续注意力能力或执行功能测量方面，包括言语或图形流畅性、非言语问题解决能力、复制复杂几何图形的能力以及视觉运动和视觉序列技能的测量，各小组之间没有差异。颅咽管瘤患者在智力和神经心理能力测量方面的小组平均得分处于低平均到平均范围。虽然颅咽管瘤患者可能有显著的发病率，包括内分泌和视觉缺陷以及由于贪食导致的肥胖，但神经心理缺陷并不总是存在。他们的神经心理结果比一些先前的研究所表明的更为良性。
