新型1-二苯甲基-哌嗪磺酰胺和甲酰胺衍生物的合成与抗菌研究
Synthesis and antimicrobial studies of novel 1-benzhydryl-piperazine sulfonamide and carboxamide derivatives.
作者信息
Kumar C S Ananda, Vinaya K, Chandra J Narendra Sharath, Thimmegowda N R, Prasad S B Benaka, Sadashiva C T, Rangappa K S
机构信息
Department of Studies in Chemistry, University of Mysore, Mysore, India.
出版信息
J Enzyme Inhib Med Chem. 2008 Aug;23(4):462-9. doi: 10.1080/14756360701654969.
A series of novel substituted 1-benzhydryl-piperazine sulfonamide 8(a-f) and benzamides 9(a-h) were synthesized and their antimicrobial activities evaluated in vitro by paper disc diffusion and micro dilution method against standard strains of Gram-positive (Staphylococcus aureus ATCC 25953, Staphylococcus epidermis 25212, Bacillus cereus 11778, Bacillus substilis 6051) and Gram-negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 2853, Proteus vulgaris ATCC 2853 and Salmonella typhi ATCC 9484) bacteria. Among the synthesized new compounds 8d, 8e, 9c, 9e, 9f and 9 h showed potent antimicrobial activities compared to the standard drug streptomycin.
合成了一系列新型取代的1-二苯甲基哌嗪磺酰胺8（a - f）和苯甲酰胺9（a - h），并通过纸片扩散法和微量稀释法对其体外抗菌活性进行了评估，测试对象为革兰氏阳性标准菌株（金黄色葡萄球菌ATCC 25953、表皮葡萄球菌25212、蜡样芽孢杆菌11778、枯草芽孢杆菌6051）和革兰氏阴性标准菌株（大肠杆菌ATCC 25922、铜绿假单胞菌ATCC 2853、普通变形杆菌ATCC 2853和伤寒沙门氏菌ATCC 9484）。在合成的新化合物中，与标准药物链霉素相比，8d、8e、9c、9e、9f和9h表现出较强的抗菌活性。
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