a Chemistry Department .
b Biology Department , and.
J Enzyme Inhib Med Chem. 2016 Dec;31(6):1005-10. doi: 10.3109/14756366.2015.1079183. Epub 2015 Aug 31.
Sulfamerazine and sulfaguanidine are clenched with p-nitrobenzoyl chloride and the products obtained are reduced to NaxS in ethanol-water. Novel sulfonamides (6a-g and 9a-g) were synthesized by the reaction of these reduced products (4 and 8) with various sulfonyl chlorides (5a-g). The structures of these compounds were characterized using spectroscopic analysis (IR, (1)H-NMR, (13)C-NMR and HRMS) technique. Antimicrobial activity of sulfonamides (3, 4, 7, 8, 6a-g and 9a-g) was evaluated by the agar diffusion method. These compounds showed antimicrobial activity against tested microorganism strains (Gram-positive bacteria, clinic isolate and yeast and mold). Compounds 9d, 9e, 9a, 6d and 6e showed particularly antimicrobial activity against tested Gram-positive (Bacillus cereus and B. subtilis) and Gram-negative (Enterobacter aerogenes) bacteria.
磺胺脒和磺胺胍与对硝基苯甲酰氯紧握，所得产物在乙醇-水中还原为 NaxS。通过还原产物（4 和 8）与各种磺酰氯（5a-g）的反应，合成了新型磺胺类化合物（6a-g 和 9a-g）。这些化合物的结构通过光谱分析（IR、（1）H-NMR、（13）C-NMR 和 HRMS）技术进行了表征。通过琼脂扩散法评估了磺胺类化合物（3、4、7、8、6a-g 和 9a-g）的抗菌活性。这些化合物对测试的微生物菌株（革兰氏阳性菌、临床分离株和酵母和霉菌）表现出抗菌活性。化合物 9d、9e、9a、6d 和 6e 对测试的革兰氏阳性（蜡样芽孢杆菌和枯草芽孢杆菌）和革兰氏阴性（产气肠杆菌）细菌表现出特别的抗菌活性。
