印度隐球菌病患者对新型隐球菌的抗体反应。
Antibody responses to Cryptococcus neoformans in Indian patients with cryptococcosis.
作者信息
Saha Dolan Champa, Xess Immaculata, Zeng Wang Yong, Goldman David L
机构信息
All India Institute of Medical Sciences, New Delhi, India.
出版信息
Med Mycol. 2008 Aug;46(5):457-63. doi: 10.1080/13693780801961345. Epub 2008 Mar 10.
An important element of the host response to cryptococcosis is humoral immunity. Specific antibody responses in patients with cryptococcosis however, have not been extensively studied. We analyzed the antibody responses of 22 Indian patients with cryptococcosis, including both HIV+ and HIV- individuals. Sera from 10 Indian patients with AIDS and without cryptococcosis were studied as controls. Antibody responses to cryptococcal proteins were detected by immunoblot, while antibodies to glucuronoxylomannan (GXM), the main component of the cryptococcal capsular polysaccharide were measured by ELISA. Our results indicate that cryptococcosis elicits antibodies to a specific pattern of cytoplasmic proteins. Further, we find that antibody responses to both cytoplasmic proteins and GXM are less robust in HIV+ patients when compared with HIV- patients.
宿主对隐球菌病反应的一个重要因素是体液免疫。然而，隐球菌病患者的特异性抗体反应尚未得到广泛研究。我们分析了22名印度隐球菌病患者的抗体反应，包括HIV阳性和HIV阴性个体。选取10名患有艾滋病且无隐球菌病的印度患者的血清作为对照。通过免疫印迹法检测对隐球菌蛋白的抗体反应，而通过酶联免疫吸附测定法测量对隐球菌荚膜多糖主要成分葡糖醛酸木甘露聚糖（GXM）的抗体。我们的结果表明，隐球菌病会引发针对特定细胞质蛋白模式的抗体。此外，我们发现，与HIV阴性患者相比，HIV阳性患者对细胞质蛋白和GXM的抗体反应较弱。
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