Monsalve Maria Victoria, Humphrey Elaine, Walker David C, Cheung Claudia, Vogl Wayne, Nimmo Mike
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Am J Phys Anthropol. 2008 Nov;137(3):348-55. doi: 10.1002/ajpa.20864.
Ancient remains preserved in glaciers present a unique opportunity for us to advance our knowledge of human origins, diversity, and health, a central focus of anthropological studies. Cellular components of hard and soft tissue from frozen human remains dated between 1670 to 1850 cal AD recovered from a glacier in Canada were studied. Despite the expected ice crystal damage in some samples, regions of recognizable structure and ultrastructure were observed. We found that the state of preservation was tissue specific and that in some tissues the organelles were better preserved than in others. Skeletal, connective, nervous, and epithelial tissues were recognizable in some of the samples. DNA had been previously extracted from these remains and this study illustrates that the ability to successfully extract DNA may correlate with good preservation of histology.
保存在冰川中的古代遗迹为我们提供了一个独特的机会，以推进我们对人类起源、多样性和健康的认识，这是人类学研究的核心重点。对从加拿大一座冰川中回收的公元1670年至1850年的冷冻人类遗骸的硬组织和软组织的细胞成分进行了研究。尽管在一些样本中预期会有冰晶损伤，但仍观察到了可识别的结构和超微结构区域。我们发现保存状态具有组织特异性，并且在某些组织中细胞器比其他组织保存得更好。在一些样本中可以识别出骨骼、结缔、神经和上皮组织。此前已从这些遗骸中提取了DNA，这项研究表明成功提取DNA的能力可能与组织学的良好保存相关。
