McGuffey R K, Basson R P, Snyder D L, Block E, Harrison J H, Rakes A H, Emery R S, Muller L D
Lilly Research Laboratories, Eli Lilly and Company, Greenfield, IN 46140.
J Dairy Sci. 1991 Apr;74(4):1263-76. doi: 10.3168/jds.S0022-0302(91)78282-9.
Lactation performance was determined on 190 multiparous Holsteins from five herds supplemented with 0, 320, 640, or 960 mg of somidobove every 28 d. The experiment consisted of 21 d of pretreatment and treatment periods of various lengths, depending upon stage of lactation of animals at first administration. Somidobove beginning in early (28 to 45 d in milk), mid (111 to 166 d in milk), or late (166 to 334 d in milk) stages of lactation consisted of 9, 6, or 3 administrations. Milk and 3.5% FCM yields were increased by each dose of somidobove in all stages. Milk composition and dry matter and energy intakes were similar among treatments within stage. Milk to DMI ratio and milk energy to net energy intake ratio were improved by somidobove. Gain was positive for all treatments, but less in somidobove-supplemented cows. Lower body weight and condition score at the completion of somidobove treatment resulted. For early cows, days to first estrus and days to first breeding were similar; however, total number of inseminations for cows receiving somidobove was twofold greater than control, resulting in a longer calving interval. Results demonstrated efficacy of somidobove administered every 28 d to lactating dairy cattle for increased milk yield.
对来自五个牛群的190头经产荷斯坦奶牛测定泌乳性能，每28天分别补充0、320、640或960毫克索米多博韦。实验包括21天的预处理期和不同长度的治疗期，具体取决于首次给药时动物的泌乳阶段。泌乳早期（产奶28至45天）、中期（产奶111至166天）或晚期（产奶166至334天）开始使用索米多博韦分别进行9次、6次或3次给药。在所有阶段，每剂索米多博韦都能提高牛奶和3.5%乳脂校正乳产量。各阶段内不同处理之间的牛奶成分、干物质摄入量和能量摄入量相似。索米多博韦可提高牛奶与干物质采食量之比以及牛奶能量与净能量摄入量之比。所有处理的增重均为正值，但补充索米多博韦的奶牛增重较少。索米多博韦治疗结束时奶牛体重和体况评分较低。对于早期奶牛，首次发情天数和首次配种天数相似；然而，接受索米多博韦的奶牛人工授精总数比对照组多一倍，导致产犊间隔延长。结果表明，每28天给泌乳奶牛施用索米多博韦可提高产奶量。
