Vaptzarova K, Hanoune J
Biochim Biophys Acta. 1976 Oct 22;444(3):712-8. doi: 10.1016/0304-4165(76)90318-4.
The effect of high level section of the spinal cord upon the hepatic cyclic AMP system was investigated in the rat. We report that transection of the spinal cord dramatically decreases the basal level of cyclic AMP from 0.88 nmol/g liver to 0.36 nmol/g at 1 h and to 0.20 nmol/g at 4 h. This was not due to increased activity of cyclic AMP phosphodiesterase or to decreased activity of basal adenylate cyclase. The sensitivity of adenylate cyclase to its usual effectors in vitro was not impaired. It is proposed that the lowering of liver cyclic AMP below its basal level after high level section of the spinal cord is due to decreased levels of hepatic catecholamines and/or plasma glucagon.
在大鼠中研究了脊髓高位横断对肝脏环磷酸腺苷（cAMP）系统的影响。我们报告，脊髓横断后，肝脏cAMP基础水平在1小时时从0.88 nmol/g急剧降至0.36 nmol/g，4小时时降至0.20 nmol/g。这并非由于环磷酸腺苷磷酸二酯酶活性增加或基础腺苷酸环化酶活性降低所致。体外腺苷酸环化酶对其常用效应器的敏感性并未受损。有人提出，脊髓高位横断后肝脏cAMP降至基础水平以下是由于肝脏儿茶酚胺和/或血浆胰高血糖素水平降低所致。
