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Moenomycin: an inhibitor of c55-isoprenoid-alcohol kinase from Staphylococcus aureus.

作者信息

Sanderman H

出版信息

Biochim Biophys Acta. 1976 Oct 22;444(3):783-8.

PMID:186107
Abstract

The effect of a variety of structurally diverse antibiotics on C55-isoprenoid-alcohol kinase (EC 2.7.1.66) from Staphylococcus aureus has been examined. Only moenomycin was found to be inhibitory (Ki = 0.2 mM). Moenocinol, the C25 lipid component of moenomycin, did not serve as a substrate of the kinase reaction and was less inhibitory than the intact antibiotic. It is concluded that the observed inhibition may be due to the structural similarity between C55-isoprenylmonophosphate and the substituted moenocinol moiety of moenomycin.

摘要

相似文献

1
Moenomycin: an inhibitor of c55-isoprenoid-alcohol kinase from Staphylococcus aureus.
Biochim Biophys Acta. 1976 Oct 22;444(3):783-8.
2
Activation of C55-isoprenoid alcohol phosphokinase from Staphylococcus aureus. I. Activation by phospholipids and fatty acids.
J Biol Chem. 1976 Mar 10;251(5):1264-9.
3
Interfacial regulation: influence of lipid polar group conformation on lipid activation of C55-isoprenoid alcohol phosphokinase apoprotein.
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4
Activation of C55-isoprenoid alcohol phosphokinase from Staphylococcus aureus. II. Biophysical studies.金黄色葡萄球菌C55-异戊二烯醇磷酸激酶的激活。II. 生物物理研究。
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5
Degradation and reconstruction of moenomycin A and derivatives: dissecting the function of the isoprenoid chain.莫能菌素A及其衍生物的降解与重构：剖析类异戊二烯链的功能
J Am Chem Soc. 2006 Nov 1;128(43):14012-3. doi: 10.1021/ja065905c.
6
The reactivation of C55-isoprenoid-alcohol-phosphokinase apoprotein by lipids. Evidence for lipid hydration in lipoprotein function.脂质对C55-异戊二烯醇磷酸激酶载脂蛋白的再激活作用。脂蛋白功能中脂质水合作用的证据。
Eur J Biochem. 1974 Apr 1;43(2):415-22. doi: 10.1111/j.1432-1033.1974.tb03427.x.
7
Activation of C55-isoprenoid alcohol phosphokinase from Staphylococcus aureus. III. Activation by detergents.金黄色葡萄球菌C55 - 异戊二烯醇磷酸激酶的激活。III. 去污剂的激活作用
J Biol Chem. 1976 Mar 10;251(5):1277-82.
8
C55-isoprenoid alcohol phosphokinase: an enzyme soluble in organic solvents.C55 - 类异戊二烯醇磷酸激酶：一种可溶于有机溶剂的酶。
Methods Enzymol. 1974;32:439-46. doi: 10.1016/0076-6879(74)32043-5.
9
Interactions of soluble penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus with moenomycin.耐甲氧西林金黄色葡萄球菌可溶性青霉素结合蛋白2a与默诺霉素的相互作用
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10
Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design.莫能菌素与肽聚糖糖基转移酶结合位点的结构分析及其对抗生素设计的启示
ACS Chem Biol. 2008 Jul 18;3(7):429-36. doi: 10.1021/cb800078a.

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