Portman O W, Alexander M, Tanaka N, Soltys P
Biochim Biophys Acta. 1976 Nov 19;450(2):185-96. doi: 10.1016/0005-2760(76)90090-4.
Low density lipoprotein apoproteins from squirrel monkeys (Saimiri sciureus) had characteristic 2-phase die-away curves in plasma. The kinetic constants were similar with three methods of labeling: in vitro with 125I by the iodine monochloride or the Bolton-Hunter methods or in vivo by the injection of [3H]-leucine into a donor animal. Dietary cholesterol and the type of dietary fat influenced the concentration of plasma cholesterol and low density lipoproteins. The fractional turnover of low density lipoprotein apoprotein was greaterin monkeys fed semipurified diets with safflower oil than in those on butter but was not influenced by dietary cholesterol. The total low density lipoprotein apoprotein turnover (the product of fractional turnover and plasma lipoprotein concentration) was highest in monkeys fed butter plus added cholesterol and lowest in those on safflower oil without cholesterol. Dietary safflower oil resulted in a smaller proportion of the total low density lipoprotein pool in the intravascular compartment than did butter, regardless of whether cholesterol was added.
松鼠猴（Saimiri sciureus）的低密度脂蛋白载脂蛋白在血浆中具有典型的两相消失曲线。三种标记方法的动力学常数相似：体外通过一氯化碘法或博尔顿-亨特法用125I标记，或体内通过向供体动物注射[3H]-亮氨酸进行标记。膳食胆固醇和膳食脂肪类型会影响血浆胆固醇和低密度脂蛋白的浓度。喂食含红花油的半纯化饮食的猴子，其低密度脂蛋白载脂蛋白的分数周转率高于喂食黄油的猴子，但不受膳食胆固醇的影响。总低密度脂蛋白载脂蛋白周转率（分数周转率与血浆脂蛋白浓度的乘积）在喂食添加胆固醇的黄油的猴子中最高，而在喂食不含胆固醇的红花油的猴子中最低。无论是否添加胆固醇，膳食红花油导致血管内 compartment 中总低密度脂蛋白池的比例比黄油小。
