Simonetto Marco, Ferigo Laura, Zanet Luca, Capus Livio, Antonutti Lucia, Zorzon Marino, Pizzolato Gilberto
Department of Experimental and Clinical Medicine and Experimental and Clinical Neurosciences, University of Trieste, Strada di Fiume 447, Trieste, Italy.
Neurol Sci. 2008 Jun;29(3):181-3. doi: 10.1007/s10072-008-0933-2. Epub 2008 Jul 9.
Acute akinesia (AA) is a rare but serious complication of Parkinson's Disease (PD) 0,3% of all patients with PD). It can be related to infectious condition, surgery, or treatment changes. AA can completely recover or result in some motor deficits, and, in the most severe forms, it may lead to untreatable complications and death. Here we report the case of a 67-year-old man with PD who rapidly developed a severe akinetic state with rise of temperature (39 degrees C) and creatine phosphokinase concentration (up to 5000 mg/dL). After excluding infection diseases and other pathologies, we suspected AA and added apomorphine 50mg/die s.c. and ondansetron 8 mg i.v. The patient responded to treatment and ameliorated in few weeks.
急性运动不能（AA）是帕金森病（PD）的一种罕见但严重的并发症（在所有PD患者中占0.3%）。它可能与感染性疾病、手术或治疗方案改变有关。AA可完全恢复或导致一些运动功能缺损，在最严重的情况下，可能会引发无法治疗的并发症并导致死亡。在此，我们报告一例67岁的PD男性患者，该患者迅速发展为严重的运动不能状态，同时伴有体温升高（39摄氏度）和肌酸磷酸激酶浓度升高（高达5000mg/dL）。在排除感染性疾病和其他病理情况后，我们怀疑是AA，并加用了皮下注射阿扑吗啡50mg/天和静脉注射昂丹司琼8mg。患者对治疗有反应，并在几周内病情好转。
