Dadon Zehavit, Wagner Nathaniel, Ashkenasy Gonen
Department of Chemistry, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.
Angew Chem Int Ed Engl. 2008;47(33):6128-36. doi: 10.1002/anie.200702552.
This Minireview gives an overview of recent progress in the design and analysis of chemical systems that utilize template-directed autocatalytic and cross-catalytic processes as a means of wiring dynamically interacting molecules. Synthetic networks comprising two to nine replicating species are discussed. It is shown that for larger systems, more catalytic pathways must be manipulated to control the entire network topology and specific functionality of the individual species or subnetworks. Cellular biochemistry is an example of a natural functional molecular network; synthetic self-organized networks can provide additional models of complex systems.
本综述概述了化学系统设计与分析方面的最新进展，这些化学系统利用模板导向的自催化和交叉催化过程作为连接动态相互作用分子的一种手段。文中讨论了包含两到九个复制物种的合成网络。结果表明，对于更大的系统，必须操纵更多的催化途径来控制整个网络拓扑结构以及各个物种或子网络的特定功能。细胞生物化学是天然功能分子网络的一个例子；合成自组织网络可以提供复杂系统的更多模型。
