Takumida Masaya, Akagi Nana, Anniko Matti
Department of Otolaryngology, Hiroshima University Faculty of Medicine, 1-2-3 Kasumicho, Minamiku, Hiroshima, Japan.
Acta Otolaryngol. 2009 Mar;129(3):244-53. doi: 10.1080/00016480802241980.
The endolymphatic sac (ES) is important for inner ear fluid homeostasis. A dysfunctional ES can cause vertigo attacks following additional stress such as a sudden change in endolymphatic volume and/or pressure, or restricted inner ear blood flow.
The purpose of this study was to elucidate the mechanism of vertigo attacks in Ménière's disease.
Adult CBA/J mice were given an intratympanic injection of lipopolysaccharide and an intraperitoneal injection of aldosterone. These 'model' animals had epinephrine or sodium nitroprusside (SNP) instilled into the middle ear cavity. Cochleae, vestibules, and endolymphatic sacs were studied morphologically by light microscopy.
The injection of epinephrine into the model animals reduced the endolymphatic hydrops in the cochlea, but also produced mild hydrops in the vestibule, which was never observed in untreated (control) animals. The ES did not react to epinephrine in the normal way. Injection of SNP did not cause any changes.
内淋巴囊（ES）对内耳液体平衡至关重要。功能失调的内淋巴囊在诸如内淋巴体积和/或压力突然变化或内耳血流受限等额外应激后可引发眩晕发作。
本研究旨在阐明梅尼埃病眩晕发作的机制。
对成年CBA/J小鼠进行鼓室内注射脂多糖和腹腔注射醛固酮。给这些“模型”动物中耳腔内滴注肾上腺素或硝普钠（SNP）。通过光学显微镜对耳蜗、前庭和内淋巴囊进行形态学研究。
给模型动物注射肾上腺素可减轻耳蜗内淋巴积水，但也在前庭产生轻度积水，这在未处理（对照）动物中从未观察到。内淋巴囊对肾上腺素未产生正常反应。注射SNP未引起任何变化。
