Marioni Gino, Staffieri Claudia, Staffieri Alberto, De Filippis Cosimo, Blandamura Stella
Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Padova, Italy.
Acta Otolaryngol. 2009 May;129(5):476-80. doi: 10.1080/00016480802256079.
A large series confirmation may suggest elective neck dissection in cN0 MASPIN-negative oral squamous cell carcinomas (SCCs). Re-activated nuclear MASPIN in association with anti-angiogenic or cytotoxic drugs may be extremely effective in the treatment of laryngeal SCC.
MASPIN is a serpin showing a unique tumour-suppressing activity. Despite the significant incidence of head and neck SCC (HNSCC), a limited number of studies has considered MASPIN's role in these malignancies. This review focuses on the attempts to translate MASPIN's HNSCC suppressive properties toward a diagnostic/prognostic tool and a novel carcinoma therapy.
A systematic literature review was performed to investigate available evidence about MASPIN subcellular localization and biological role in HNSCC.
Five studies have investigated MASPIN's expression in oral SCC. Most of them concluded that low or absent MASPIN cytoplasmic expression was more frequent in oral carcinomas with lymph node metastases. Only our group evaluated MASPIN's role in laryngeal SCC. Higher nuclear MASPIN expression was found in patients without SCC recurrence and was significantly associated with longer disease-free survival. Micro-vascular density was lower in laryngeal carcinomas with MASPIN nuclear staining. The relation between MASPIN and M30-assessed apoptosis in laryngeal SCC supports the hypothesis of an important apoptosis-sensitizing effect of nuclear MASPIN.
大量病例证实可能提示，对于cN0、MASPIN阴性的口腔鳞状细胞癌（SCC）可考虑选择性颈部淋巴结清扫术。重新激活的细胞核MASPIN联合抗血管生成或细胞毒性药物可能对喉SCC的治疗极为有效。
MASPIN是一种丝氨酸蛋白酶抑制剂，具有独特的肿瘤抑制活性。尽管头颈部SCC（HNSCC）发病率很高，但仅有少数研究探讨了MASPIN在这些恶性肿瘤中的作用。本综述重点关注将MASPIN对HNSCC的抑制特性转化为诊断/预后工具及新型癌症治疗方法的尝试。
进行系统的文献综述，以研究关于MASPIN在HNSCC中的亚细胞定位和生物学作用的现有证据。
五项研究调查了MASPIN在口腔SCC中的表达。其中大多数得出结论，在有淋巴结转移的口腔癌中，MASPIN胞质低表达或无表达更为常见。只有我们的团队评估了MASPIN在喉SCC中的作用。在无SCC复发的患者中发现细胞核MASPIN表达较高，且与更长的无病生存期显著相关。细胞核MASPIN染色的喉癌中微血管密度较低。MASPIN与通过M30评估的喉SCC细胞凋亡之间的关系支持细胞核MASPIN具有重要的促凋亡作用这一假说。
