Yang Y, Jacobs H, Bae Y H, Kim S W
Center for Controlled Chemical Delivery/Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84108.
Biotechnol Bioeng. 1994 Feb 5;43(3):207-14. doi: 10.1002/bit.260430304.
A new composite membrane was designed and studied for permselectivity of various molecular weight proteins. The membrane is composed of a porous substrate membrane [Durapore; poly(vinylidene fluoride)] coated with a thin dense layer of regenerated cellulose. This composite membrane was fabricated by spin coating a cellulose acetate solution onto the membrane, followed by alkaline hydrolysis of the cellulose acetate coating to regenerate cellulose. The coated layer was physically characterized by scanning electron microscopy (SEM) and infrared (IR) spectroscopy. In addition, the water uptake into and permeation properties of macromolecules across the coated and uncoated membranes were studied. A typical composite membrane coating was 0.8 +/- 0.2 mum thick, resulting in a molecular weight cutoff of approximately 40,000 daltons. This composite membrane also demonstrated negligible diffusional lag time for permeants, due to the diffusional barrier. (c) 1994 John Wiley & Sons, Inc.
设计并研究了一种新型复合膜，用于对各种分子量蛋白质的渗透选择性。该膜由涂覆有一层薄致密再生纤维素层的多孔基底膜[聚偏氟乙烯微孔滤膜（Durapore）]组成。通过将醋酸纤维素溶液旋涂到膜上，然后对醋酸纤维素涂层进行碱性水解以再生纤维素，制备了这种复合膜。通过扫描电子显微镜（SEM）和红外（IR）光谱对涂层进行了物理表征。此外，还研究了水进入以及大分子穿过涂覆和未涂覆膜的渗透特性。典型的复合膜涂层厚度为0.8±0.2μm，截留分子量约为40,000道尔顿。由于扩散屏障，这种复合膜对渗透物的扩散滞后时间也可忽略不计。（c）1994约翰·威利父子公司。
