极低出生体重波多黎各新生儿的体重增加率。
Rate of weight gain in very-low birth weight Puerto Rican neonates.
作者信息
Campos Maribel, García Lourdes, García Inés E, Rivera Cynthia, Valcárcel Marta I
机构信息
University of Puerto Rico School of Medicine, Department of Pediatrics, Neonatology Section.
出版信息
P R Health Sci J. 2008 Jun;27(2):141-5.
BACKGROUND
Small for gestational age neonates have a higher risk of growth delay. The purpose of the study is to determine if there are differences in their early weight gain patterns that persist after adjusting for confounding variables.
METHODS
Two-hundred sixteen neonates born between 1999 and 2003 were included. The group for analysis was derived by matching all the SGA infants with AGA infants by sex, year of birth, and birth weight. The period of observation was from birth to date of discharge. Weight gain rate was defined as grams gained per kilogram of birth weight per day. Two sample T-test was used to determine the difference in growth rate between the groups. Simple regression was used to establish the effect of morbidities on weight gain rate.
RESULTS
The total mean birth weight was 1105 g (+/- 223 g), the mean gestational age was 30 weeks (+/- 2.7 weeks), and the mean weight gain rate was 13.4 g/kg/d (+/- 6.8 g/kg/d). The mean weight gain rate for the adequate for gestational age group was lower (11.9 g/kg/d +/- 7.6g versus 14.9 g/kg/d +/- 5.5 g) (P < 0.001). When all variables were analyzed using the lineal regression model, only having a low APGAR score (P = 0.02) and being small for gestational age (P = 0.0004) were significant.
CONCLUSIONS
We conclude that the growth patterns of very low birth weight neonates are different based on the adequacy of their birth weight, and that the disparity in growth rate is not explained by the differences in the incidence of morbidities that affect growth.
背景
小于胎龄儿发生生长发育迟缓的风险较高。本研究的目的是确定在调整混杂变量后，其早期体重增加模式是否存在持续差异。
方法
纳入1999年至2003年间出生的216例新生儿。通过按性别、出生年份和出生体重将所有小于胎龄儿与适于胎龄儿进行匹配来确定分析组。观察期从出生至出院。体重增加率定义为每天每千克出生体重增加的克数。采用两样本t检验确定两组之间生长率的差异。采用简单回归分析确定疾病对体重增加率的影响。
结果
总平均出生体重为1105 g（±223 g），平均胎龄为30周（±2.7周），平均体重增加率为13.4 g/kg/d（±6.8 g/kg/d）。适于胎龄组的平均体重增加率较低（11.9 g/kg/d±7.6 g对14.9 g/kg/d±5.5 g）（P<0.001）。当使用线性回归模型分析所有变量时，只有低Apgar评分（P = 0.02）和小于胎龄（P = 0.0004）具有统计学意义。
结论
我们得出结论，极低出生体重儿的生长模式因其出生体重是否合适而有所不同，且生长率的差异不能用影响生长的疾病发生率差异来解释。
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