非器质性生长发育迟缓的阳性诊断方式
Diagnosis on a positive fashion of nonorganic failure to thrive.
作者信息
Panetta Fabio, Magazzù Domenico, Sferlazzas Concetta, Lombardo Mariangela, Magazzù Giuseppe, Lucanto Maria Cristina
机构信息
Cystic Fibrosis and Paediatric Gastroenterology Unit, University of Messina, Messina, Italy.
出版信息
Acta Paediatr. 2008 Sep;97(9):1281-4. doi: 10.1111/j.1651-2227.2008.00912.x.
AIMS
To study the predictive value of predefined symptoms and signs for allocating children into one of two groups: nonorganic and organic failure to thrive.
PATIENTS AND METHODS
Two hundred eight outpatients (6 months-14 years old) suffering from failure to thrive (FTT) were included in the study. Predefined symptoms and signs were considered as potential predictors of organic/nonorganic failure to thrive. All patients underwent an established diagnostic work up in order to exclude organic causes of FTT.
RESULTS
The percentage of patients without any organic symptom (negative predictive value), who were diagnosed as NOFTT was 92%; the percentage of patients having nonorganic symptoms only (positive predictive value), who were diagnosed as NOFTT was 96%, while their absence does not exclude a NOFTT diagnosis as well (negative predictive value = 41%).
CONCLUSION
The detection of at least one nonorganic symptom or sign, with the exclusion of any organic symptom, can support a diagnosis of nonorganic FTT and therefore only few laboratory investigations seem to be warranted.
目的
研究预先定义的症状和体征对于将儿童分为两组的预测价值，这两组分别为非器质性和器质性生长发育迟缓。
患者与方法
本研究纳入了208名患有生长发育迟缓（FTT）的门诊患者（年龄在6个月至14岁之间）。预先定义的症状和体征被视为器质性/非器质性生长发育迟缓的潜在预测指标。所有患者均接受了既定的诊断检查，以排除FTT的器质性病因。
结果
被诊断为非器质性生长发育迟缓且无任何器质性症状的患者百分比（阴性预测值）为92%；仅具有非器质性症状且被诊断为非器质性生长发育迟缓的患者百分比（阳性预测值）为96%，而这些症状的缺失也不能排除非器质性生长发育迟缓的诊断（阴性预测值 = 41%）。
结论
检测到至少一种非器质性症状或体征，同时排除任何器质性症状，可支持非器质性FTT的诊断，因此似乎仅需进行少量实验室检查。
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