Myerowitz R L, Sartiano G P, Cavallo T
Cancer. 1976 Oct;38(4):1550-5. doi: 10.1002/1097-0142(197610)38:4<1550::aid-cncr2820380417>3.0.co;2-t.
The nephrotoxic and cytoproliferative side effects observed in a patient with Streptozotocin-treated, multiple hormone-secreting, pancreatic islet cell carcinoma are described. Streptozotocin induced prolonged partial remission of the patient's multiendocrine syndrome but resulted in progressive azotemia, which was controlled by temporary hemodialysis. A renal biopsy, the first to be reported in detail in such a condition, demonstrated a tubulo-interstitial nephritis and a glomerular alteration consisting of cellular nodules. At autopsy there were numerous bilateral renal cortical spindle cell "tumors" and cellular aggregates in glomeruli. These findings suggest that the tumorigenic effects of Streptozotocin demonstrated in animals may also occur in man.
本文描述了一名接受链脲佐菌素治疗的多发性内分泌分泌性胰岛细胞癌患者所观察到的肾毒性和细胞增殖性副作用。链脲佐菌素使患者的多内分泌综合征得到了长时间的部分缓解，但导致了进行性氮质血症，通过临时血液透析得以控制。肾活检在此类病症中首次被详细报道，显示为肾小管间质性肾炎以及由细胞结节构成的肾小球改变。尸检发现双侧肾皮质有大量梭形细胞“肿瘤”以及肾小球内的细胞聚集。这些发现表明，链脲佐菌素在动物身上所显示的致瘤作用在人类身上也可能发生。
