Färnert Anna
Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, SE-17176 Stockholm, Sweden.
Trends Parasitol. 2008 Aug;24(8):340-4. doi: 10.1016/j.pt.2008.04.008. Epub 2008 Jul 9.
Infections caused by the malaria parasite Plasmodium falciparum often comprise multiple genetically distinct clones. Individuals in endemic areas can have different clones detected in their peripheral blood over a few days or even hours. This reveals interesting within-host dynamics of multiclonal infections, which seem to differ in asymptomatic and symptomatic infections. As well as being an intriguing biological phenomenon that merits further understanding, the extensive dynamics of P. falciparum infections have practical implications on the design and interpretation of malaria studies. Most assessments will, indeed, only provide snapshots of the parasite population dynamics.
由恶性疟原虫引起的感染通常包含多个基因不同的克隆体。流行地区的个体在几天甚至几小时内，外周血中可检测到不同的克隆体。这揭示了多克隆感染在宿主体内有趣的动态变化，无症状感染和有症状感染中的情况似乎有所不同。除了是一种值得进一步了解的有趣生物学现象外，恶性疟原虫感染的广泛动态变化对疟疾研究的设计和解读具有实际意义。实际上，大多数评估仅能提供寄生虫种群动态的快照。
