盐酸金刚烷胺对淋巴细胞性脉络丛脑膜炎病毒与细胞相互作用早期和晚期的抑制作用。
Amantadine hydrochloride inhibition of early and late stages of lymphocytic choriomeningitis virus-cell interactions.
作者信息
Welsh R M, Trowbridge R S, Kowalski J B, O'Connell C M, Pfau C J
机构信息
Department of Microbiology, University of Massachusetts, Amherst, Massachusetts 01002, USA.
出版信息
Virology. 1971 Sep;45(3):679-86.
Amantadine hydrochloride inhibits the CA1371, UBC, and WE strains of LCM in both BHK21/13S and L-929 cells. The compound has no direct inactivating effect on virus infectivity nor does it affect the adsorption of virus to cells. By observing the susceptibility of cell-adsorbed virus to neutralizing antibody, amantadine was shown to delay virion penetration. Furthermore, addition of the drug at any time during ongoing viral replication, with all cells scoring as infective centers, inhibits virus synthesis and release.
盐酸金刚烷胺在BHK21/13S细胞和L - 929细胞中均能抑制淋巴细胞脉络丛脑膜炎病毒（LCM）的CA1371、UBC和WE毒株。该化合物对病毒感染性没有直接灭活作用，也不影响病毒对细胞的吸附。通过观察细胞吸附病毒对中和抗体的敏感性，发现金刚烷胺可延迟病毒粒子的穿透。此外，在病毒持续复制过程中的任何时间添加该药物，所有细胞均作为感染中心，可抑制病毒的合成和释放。
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