Pawlyk Aaron C, Alfinito Peter D, Deecher Darlene C
Women's Health & Musculoskeletal Biology, Wyeth Research, Collegeville, PA 19426, USA.
Eur J Pharmacol. 2008 Sep 4;591(1-3):315-8. doi: 10.1016/j.ejphar.2008.06.084. Epub 2008 Jun 27.
Estrogen treatment decreases active phase rapid eye movement (REM) sleep in ovariectomized rats. Here we explored further the effect of 17alpha-ethinyl estradiol (17alpha-EE) on active phase REM sleep in ovariectomized rats by analyzing spectral properties and the number and length of REM sleep bouts. The greatest suppression of REM sleep occurred on day 4 of 17alpha-EE treatment, was due to decreases in bout length, and was accompanied by decreased EEG theta power. These results further elucidate 17alpha-EE's effects on REM sleep and provide greater understanding of the mechanisms by which estrogens alter sleep-wakefulness patterns.
雌激素治疗可减少去卵巢大鼠活跃期快速眼动（REM）睡眠。在此，我们通过分析频谱特性以及REM睡眠发作的次数和时长，进一步探究了17α-乙炔雌二醇（17α-EE）对去卵巢大鼠活跃期REM睡眠的影响。REM睡眠的最大抑制出现在17α-EE治疗的第4天，这是由于发作时长缩短所致，同时伴有脑电图θ波功率降低。这些结果进一步阐明了17α-EE对REM睡眠的影响，并加深了我们对雌激素改变睡眠-觉醒模式机制的理解。
