粗齿艾麻的抗菌和细胞毒性活性。

Antimicrobial and cytotoxic activities of Laportea crenulata.

作者信息

Rahman M Mukhlesur, Khan Alam, Haque M Ekramul, Rahman M Motiur

机构信息

Phytochemistry Research Laboratories, Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh.

出版信息

Fitoterapia. 2008 Dec;79(7-8):584-6. doi: 10.1016/j.fitote.2008.04.007. Epub 2008 Jun 22.

DOI:10.1016/j.fitote.2008.04.007

PMID:18621115

Abstract

Crude extracts and 2alpha,3beta,21beta,24beta,28-pentahydroxy-olean-12-ene (1) obtained from the root of Laportea crenulata exhibited remarkable antibacterial activities against both Gram (+) and Gram (-) bacteria. The antifungal activities of crude extracts and compound (1) were also determined. The cytotoxic activities of crude extracts and compound (1) were observed by brine shrimp bioassay and LC(50) value of the compound (1) was found to be 27.54 microg/ml.

摘要

从粗齿艾麻根中获得的粗提物和2α,3β,21β,24β,28 - 五羟基 - 齐墩果 - 12 - 烯（1）对革兰氏阳性菌和革兰氏阴性菌均表现出显著的抗菌活性。还测定了粗提物和化合物（1）的抗真菌活性。通过卤虫生物测定法观察了粗提物和化合物（1）的细胞毒性活性，发现化合物（1）的LC50值为27.54微克/毫升。