Geagea Antoine, Cellier Christophe
Department of Gastroenterology, European Georges Pompidou Hospital, Paris, France.
Curr Opin Gastroenterol. 2008 Jul;24(4):496-501. doi: 10.1097/MOG.0b013e328304de94.
The most common cause of esophageal injury is gastroesophageal reflux disease, however other less recognized causes may affect the esophagus. In this review we will focus on pill-induced esophageal injury, infections of the esophagus and eosinophilic esophagitis.
Esophageal infections are less frequent since HIV infection has become better controlled with antiviral therapies. The most emergent 'allergic' disease of the esophagus is eosinophilic esophagitis, which has become increasingly recognized in children and adults over the last decade. Eosinophilic esophagitis is a clinicopathologic disorder characterized by a dense esophageal eosinophilia generally occurring in association with upper gastrointestinal symptoms, primarily intermittent dysphagia, and refractory to proton pump inhibitor therapy.
Drug-induced esophageal injury remains underdiagnosed and should be better recognized.
食管损伤最常见的原因是胃食管反流病，但其他不太为人所知的原因也可能影响食管。在本综述中，我们将重点关注药物性食管损伤、食管感染和嗜酸性粒细胞性食管炎。
随着抗逆转录病毒疗法对HIV感染的控制越来越好，食管感染的发生率有所降低。食管最常见的“过敏性”疾病是嗜酸性粒细胞性食管炎，在过去十年中，儿童和成人中对其的认识越来越多。嗜酸性粒细胞性食管炎是一种临床病理障碍，其特征是食管嗜酸性粒细胞密集，通常与上消化道症状相关，主要是间歇性吞咽困难，对质子泵抑制剂治疗无效。
药物性食管损伤仍未得到充分诊断，应提高认识。
