Panush R S
University of Medicine and Dentistry of New Jersey, New Jersey Medical School.
Rheum Dis Clin North Am. 1991 May;17(2):251-7.
Progress in understanding rheumatoid arthritis has been slow in large part because no widely accepted animal model exists that clearly reflects naturally occurring human disease, and because the clinical expression of rheumatoid arthritis may represent multiple etiologies with shared or subtly different immunopathogenic pathways. New insights about pathogenesis and causes are needed to understand this disease and ultimately to care for patients better.
在很大程度上,对类风湿性关节炎的理解进展缓慢,原因在于不存在一种被广泛接受的、能清晰反映自然发生的人类疾病的动物模型,还在于类风湿性关节炎的临床症状可能代表多种病因,这些病因有着共同的或细微不同的免疫致病途径。需要对发病机制和病因有新的见解,才能理解这种疾病,并最终更好地照顾患者。