Mehdizadeh Alireza, Fazelzadeh Afsoon, Karimi Hamed
Int J Cardiol. 2009 Aug 14;136(2):220-1. doi: 10.1016/j.ijcard.2008.04.036. Epub 2008 Jul 14.
In-stent Restenosis (ISR) is the Achilles heel for using of stent. Vascular brachytherapy (VBT) has been the principal scientifically investigated local therapy for coronary artery ISR. In our suggested method, a new type of stent, which is coated with Boron ((10)B) compound, is used. The coating layer of the stent consists of stable isotype of (10)B. Boron Neutron Capture Therapy produced alpha particle has enough energy to kill the cells adjacent to the stent, which is the site of boron deposition. It would prevent from ISR and intimal proliferation. After percutaneous coronary intervention (PCI) and insertion of stent, follow-up should be done continuously, and if ISR is detected, BNCT will be used to treat the recurrence. Using this modality of VBT would help us to overcome the pitfalls in en vogue radiotherapy methods.
支架内再狭窄（ISR）是使用支架的致命弱点。血管近距离放射治疗（VBT）一直是针对冠状动脉ISR进行科学研究的主要局部治疗方法。在我们建议的方法中，使用了一种新型的涂有硼（¹⁰B）化合物的支架。支架的涂层由稳定的¹⁰B同位素组成。硼中子俘获疗法产生的α粒子具有足够的能量杀死与支架相邻的细胞，而支架部位正是硼沉积的地方。这将预防ISR和内膜增生。经皮冠状动脉介入治疗（PCI）并植入支架后，应持续进行随访，如果检测到ISR，将使用硼中子俘获疗法治疗复发情况。采用这种VBT方式将有助于我们克服当前流行的放射治疗方法中的缺陷。
