Herling A W, Kilp S, Juretschke H-P, Neumann-Haefelin C, Gerl M, Kramer W
Therapeutic Department Metabolism, Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany.
Int J Obes (Lond). 2008 Sep;32(9):1363-72. doi: 10.1038/ijo.2008.105. Epub 2008 Jul 15.
The severity of obesity is often more determined by the distribution of fat depots rather than by body weight itself. Therefore, the effect of rimonabant on fat distribution pattern was investigated in female candy-fed Wistar rats.
Female Wistar rats were fed a high fat, high carbohydrate (candy-) diet for 12 weeks. During the last 6 weeks rats were treated with rimonabant. Food intake and body weight development were investigated, as well as effects on total body fat, especially visceral fat and ectopic lipid accumulation in skeletal muscle and liver, determined by in vivo magnetic resonance imaging/magnetic resonance spectroscopy.
Candy-diet increased body weight, which was predominantly due to the increased total fat mass with predominance of visceral fat accumulation. Treatment with rimonabant fully reversed the weight gain and fat deposition in the visceral cavity and skeletal muscle, in contrast to pair feeding. In spite of an only transient reduction of food intake, body weight reduction, as well as normalized body fat, reduced visceral fat and intramyocellular lipids were maintained over the treatment period.
We conclude that additional factors other than reduced caloric intake must be responsible for the improvements in these lipid parameters. The complete cluster of results is consistent with increased lipid oxidation caused by rimonabant.
肥胖的严重程度通常更多地取决于脂肪储存部位的分布，而非体重本身。因此，在喂食糖果的雌性Wistar大鼠中研究了利莫那班对脂肪分布模式的影响。
将雌性Wistar大鼠喂食高脂肪、高碳水化合物（糖果）饮食12周。在最后6周，大鼠接受利莫那班治疗。研究了食物摄入量和体重变化，以及通过体内磁共振成像/磁共振波谱法测定的对全身脂肪，尤其是内脏脂肪以及骨骼肌和肝脏中异位脂质蓄积的影响。
糖果饮食增加了体重，这主要归因于总脂肪量增加，以内脏脂肪蓄积为主。与配对喂食相比，利莫那班治疗完全逆转了体重增加以及内脏腔和骨骼肌中的脂肪沉积。尽管食物摄入量仅短暂减少，但在治疗期间体重减轻以及身体脂肪正常化、内脏脂肪减少和肌细胞内脂质减少得以维持。
我们得出结论，除热量摄入减少外，其他因素必定是这些脂质参数改善的原因。完整的结果集与利莫那班引起的脂质氧化增加一致。
