育亨宾对突触前α-肾上腺素能受体的选择性阻断作用。
Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine.
作者信息
Starke K, Borowski E, Endo T
出版信息
Eur J Pharmacol. 1975 Dec;34(2):385-8. doi: 10.1016/0014-2999(75)90268-x.
PMID:186273
Abstract
Strips of the rabbit main pulmonary artery were preincubated with 3H-noradrenaline. 3 X 10(-8) -- 10(6) M yohimbine enhanced the overflow of tritium and the smooth muscle contraction induced by transmural sympathetic nerve stimulation. The increase of the stimulation-evoked overflow of tritium was prevented by a high concentration of oxymetazoline. The results indicate that yohimbine is more potent in blocking the presynaptic than the postsynaptic alpha-adrenoceptors of the artery.
摘要
将兔主肺动脉条与3H-去甲肾上腺素一起预孵育。3×10(-8) -- 10(6)M育亨宾增强了经壁交感神经刺激诱导的氚外流和平滑肌收缩。高浓度的奥昔美唑啉可阻止刺激诱发的氚外流增加。结果表明，育亨宾阻断动脉突触前α-肾上腺素能受体比阻断突触后α-肾上腺素能受体更有效。
Zotero 插件