在大鼠炎症部位检测到的细胞外磷脂酶A2并非源自血小板。

Extracellular phospholipase A2 detected at inflamed sites in rats does not originate from platelets.

作者信息

Mori H, Hara S, Mizushima H, Kudo I, Sato Y, Inoue K

机构信息

Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.

出版信息

Agents Actions. 1991 Mar;32(3-4):266-9. doi: 10.1007/BF01980884.

DOI:10.1007/BF01980884

PMID:1862745

Abstract

Extracellular phospholipase A2 activity has been detected in caseinate-induced peritoneal fluid in rats. We studied the source of this extracellular phospholipase A2 in 'platelet-poor' rats which had been pretreated with an intravenous injection of rabbit anti-rat platelet serum. In these rats, the increase in the peritoneal fluid extracellular phospholipase A2 level at the inflamed sites was almost identical to that observed in control rats, although platelet numbers in peripheral blood were decreased markedly. This observation suggests that extracellular phospholipase A2 in the peritoneal cavity is not derived mainly from platelets.

摘要

在酪蛋白诱导的大鼠腹腔液中已检测到细胞外磷脂酶A2活性。我们研究了用静脉注射兔抗大鼠血小板血清预处理的“血小板减少”大鼠中这种细胞外磷脂酶A2的来源。在这些大鼠中，尽管外周血中的血小板数量明显减少，但炎症部位腹腔液细胞外磷脂酶A2水平的升高与对照大鼠中观察到的几乎相同。这一观察结果表明，腹腔中的细胞外磷脂酶A2并非主要来源于血小板。