Allan Charlotte L, Cardno Alastair G, McGuffin Peter
Academic Unit of Psychiatry and Behavioral Sciences, Leeds Institute of Health Sciences, University of Leeds, Charles Thackrah Building, 101 Clarendon Road, Leeds LS2 9LJ, United Kingdom.
Curr Psychiatry Rep. 2008 Aug;10(4):339-43. doi: 10.1007/s11920-008-0054-x.
This article provides an overview of the past year's literature on schizophrenia genetics. Quantitative genetics continues to be an important foundation in which family and twin studies have been used to evaluate potential endophenotypes. Research in molecular genetics has focused on detecting multiple genes of small effect, and developments relating to key positional and functional candidate genes are reviewed. Large-scale, multicenter studies are proving to be important in this quest. Research using neuroimaging and animal modeling studies continues to link genotype with phenotype. It is increasingly apparent that some candidate genes considered important in schizophrenia are likely to be relevant to the etiology of other psychotic disorders, including bipolar disorder. This notion may challenge traditional disease classifications, not only in research but potentially in clinical practice.
本文概述了过去一年关于精神分裂症遗传学的文献。数量遗传学仍然是一个重要基础，其中家族和双生子研究已被用于评估潜在的内表型。分子遗传学研究聚焦于检测多个小效应基因，并对与关键定位和功能候选基因相关的进展进行了综述。大规模、多中心研究在这一探索过程中被证明很重要。使用神经影像学和动物模型的研究继续将基因型与表型联系起来。越来越明显的是，一些在精神分裂症中被认为重要的候选基因可能与包括双相情感障碍在内的其他精神障碍的病因相关。这一观念可能会挑战传统的疾病分类，不仅在研究中如此，在临床实践中也可能如此。
