从基因调控到基因功能：枯草芽孢杆菌中的调控网络
From gene regulation to gene function: regulatory networks in bacillus subtilis.
作者信息
Harwood Colin R, Moszer Ivan
机构信息
Department of Microbiology and Immunology,The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
出版信息
Comp Funct Genomics. 2002;3(1):37-41. doi: 10.1002/cfg.138.
Abstract
Bacillus subtilis is a sporulating Gram-positive bacterium that lives primarily in the soil and associated water sources. The publication of the B. subtilis genome sequence and subsequent systematic functional analysis and gene regulation programmes, together with an extensive understanding of its biochemistry and physiology, makes this micro-organism a prime candidate in which to model regulatory networks in silico. In this paper we discuss combined molecular biological and bioinformatical approaches that are being developed to model this organism's responses to changes in its environment.
摘要
枯草芽孢杆菌是一种形成芽孢的革兰氏阳性细菌，主要生活在土壤及相关水源中。枯草芽孢杆菌基因组序列的公布、随后的系统功能分析和基因调控程序，以及对其生物化学和生理学的广泛了解，使这种微生物成为在计算机上模拟调控网络的主要候选对象。在本文中，我们讨论了正在开发的结合分子生物学和生物信息学的方法，以模拟这种生物体对环境变化的反应。
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