Simpson A J, de Souza S J, Camargo A A, Brentani R R
The Ludwig Institute for Cancer Research, Rua Professor Antônio Prudente 109, São Paulo, SP 01509-010, Brazil.
Comp Funct Genomics. 2001;2(3):169-75. doi: 10.1002/cfg.81.
Based on the analysis of the drafts of the human genome sequence, it is being speculated that our species may possess an unexpectedly low number of genes. The quality of the drafts, the impossibility of accurate gene prediction and the lack of sufficient transcript sequence data, however, render such speculations very premature. The complexity of human gene structure requires additional and extensive experimental verification of transcripts that may result in major revisions of these early estimates of the number of human genes.
基于对人类基因组序列草图的分析，有人推测我们这个物种可能拥有数量低得出乎意料的基因。然而，草图的质量、准确预测基因的不可能性以及缺乏足够的转录本序列数据，使得这种推测为时过早。人类基因结构的复杂性需要对转录本进行更多广泛的实验验证，而这可能会导致对这些人类基因数量的早期估计进行重大修正。
