Prozorovskiĭ V B, Iudkina N I
Anesteziol Reanimatol. 1991 Jan-Feb(1):25-6.
The effect of anesthesia with ketamine (80 mg/kg, intraperitoneally) combined with phenazepam (0.5 mg/kg, subcutaneously) on the reproduction of an elaborated active avoidance reflex in automated reflexometer has been studied on random bred white rats. In has been shown that during 3 hours after the animal is taken out of the lateral position the degree of its learning is significantly lowered and does not return to baseline even a day later. Intramuscular administration of a new cholinesterase inhibitor aminostigmine right after the end of anesthesia restores the disrupted reflex in 3 hours. The optimal antistigmine dose is 0.015 mg/kg, which corresponds to a therapeutic human dose.
在随机繁殖的白色大鼠身上，研究了氯胺酮（80毫克/千克，腹腔注射）联合非那西泮（0.5毫克/千克，皮下注射）麻醉对自动反射计中精细主动回避反射重现的影响。结果表明，动物从侧卧姿势取出后的3小时内，其学习程度显著降低，甚至一天后也未恢复到基线水平。麻醉结束后立即肌肉注射一种新型胆碱酯酶抑制剂氨基新斯的明，3小时后可恢复被打乱的反射。最佳抗胆碱酯酶剂量为0.015毫克/千克，这相当于人类治疗剂量。
