瞬时受体电位香草酸亚型（TRPV）在人喉中的定位。
Localization of transient receptor potential vanilloid (TRPV) in the human larynx.
作者信息
Hamamoto Takao, Takumida Masaya, Hirakawa Katsuhiro, Tatsukawa Takaharu, Ishibashi Takuya
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
出版信息
Acta Otolaryngol. 2009 May;129(5):560-8. doi: 10.1080/00016480802273108.
CONCLUSION
Transient receptor potential vanilloid (TRPV) 1, 2, 3, and 4 were expressed in the human larynx, which may act as laryngeal nociceptors perceiving luminal noxious stimuli, play an important role in thermal sensation and osmotic sensation, and are also related to some pathological conditions and prevention of aspiration.
OBJECTIVE
Expression of TRPV1, 2, 3, and 4 in the human larynx was analyzed.
MATERIALS AND METHODS
Specimens of human epiglottic epithelium obtained from six patients were used in this study. The localization of TRPV1, 2, 3, and 4 in the laryngeal epithelium was investigated by immunohistochemistry.
RESULTS
Immunohistochemical study revealed the presence of TRPV1, 2, 3, and 4 in the laryngeal epithelial cells. Chemoradiotherapy may reduce the expression of TRPV1, 2, 3, and 4, which might be a result of the mucositis and neuropathy in laryngeal epithelium.
结论
瞬时受体电位香草酸亚型（TRPV）1、2、3和4在人喉中表达，它们可能作为喉伤害感受器感知管腔内的有害刺激，在热感觉和渗透压感觉中起重要作用，并且还与一些病理状况及误吸的预防有关。
目的
分析TRPV1、2、3和4在人喉中的表达情况。
材料与方法
本研究使用了从6例患者获取的会厌上皮标本。通过免疫组织化学研究TRPV1、2、3和4在喉上皮中的定位。
结果
免疫组织化学研究显示喉上皮细胞中存在TRPV1、2、3和4。放化疗可能会降低TRPV1、2、3和4的表达，这可能是喉上皮黏膜炎和神经病变的结果。
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