[Y染色体微缺失作为男性不育的预后标志物]
[Y-chromosome microdeletions as a prognostic marker of male infertility].
作者信息
Tyrkus M Ia, Makukh H V, Zastavna D V, Huleiuk N L, Nakonechnyĭ A I, Stoĭka B R
出版信息
Tsitol Genet. 2008 Mar-Apr;42(2):46-50.
The results of molecular-genetic study of Y-chromosome microdeletions in men with spermatogenesis failure and in patients with cryptorchism are presented. The molecular-genetic studies of regions AZFa, AZFb, AZFc in STS loci - sY84, sY86, sY127, sY134, sY254, sY255 and SRY gene have been performed. Y-chromosome microdeletions were detected in 13,3% infertile men with spermogram failure. The frequency of genetic (cyto- and molecular) abnormalities among boys with isolated cryptorchism was 4%. The results show the necessity of additional study ofgenetic factors ofcryptorchism development.
本文展示了对精子发生失败男性和隐睾症患者Y染色体微缺失的分子遗传学研究结果。已对STS基因座（sY84、sY86、sY127、sY134、sY254、sY255）中的AZFa、AZFb、AZFc区域以及SRY基因进行了分子遗传学研究。在精液检查失败的13.3%不育男性中检测到Y染色体微缺失。孤立性隐睾男孩中遗传（细胞和分子）异常的发生率为4%。结果表明有必要进一步研究隐睾症发生的遗传因素。
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