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[子宫异常出血患者子宫内膜息肉的患病率及特征]

[Prevalence and characteristics of endometrial polyps in patients with abnormal uterine bleeding].

出版信息

Vojnosanit Pregl. 2008 May;65(5):349-52. doi: 10.2298/vsp0805349d.

Abstract

BACKGROUND/AIM: The prevalence of endometrial polyps (EPs) in the general female population is about 24%. Abnormal uterine bleeding is frequently the presenting symptom of EPs. The aim of this study was to determine the prevalence and characteristics of EPs in patients with abnormal uterine bleeding.

METHODS

The prevalence and characteristics of EPs were investigated in 961 patients with abnormal uterine bleeding who underwent dilatation and curettage between January and December 2006. Regarding histopathological features of EPs (presence of atypical hyperplasia or endometrial carcinoma), patients were divided into two groups: group A--patients who had EPs and EPs with hyperplasia without atypia (n = 204) and group B--patients who had EPs with atypical hyperplasia and EPs with carcinoma (n = 7).

RESULTS

In 211 (21.94%) patients EPs were found with abnormal uterine bleeding. Histopathologically, there were 175 (82.94%) EPs, 29 (13.74%) EPs with hyperplasia without atypia, 5 (2.37%) EPs with atypical hyperplasia, and 2 (0.95%) EPs with endometrial carcinoma. Contrary to the patients with EPs and EPs with hyperplasia without atypia (group A), patients who had EPs with atypical hyperplasia and EPs with carcinoma (group B) were older (p < 0.05), and more commonly postmenopausal (p < 0.05) and with hypertension (p < 0.05), all of statistical significance.

CONCLUSION

The prevalence of endometrial polyps in patients with abnormal uterine bleeding according to our data was 21.95%. Atypical hyperplasia and endometrial carcinoma were rarely confined to a polyp. Older age, postmenopausal period and hypertension may increase the risk of premalignant and malignant changes in endometrial polyps.

摘要

背景/目的:子宫内膜息肉(EP)在普通女性人群中的患病率约为24%。子宫异常出血常常是EP的首要症状。本研究旨在确定子宫异常出血患者中EP的患病率及特征。

方法

对2006年1月至12月期间961例行刮宫术的子宫异常出血患者的EP患病率及特征进行研究。根据EP的组织病理学特征(非典型增生或子宫内膜癌的存在情况),将患者分为两组:A组——患有EP及无非典型增生的增生性EP的患者(n = 204);B组——患有非典型增生性EP及癌性EP的患者(n = 7)。

结果

在211例(21.94%)子宫异常出血患者中发现了EP。组织病理学检查显示,有175例(82.94%)为EP,29例(13.74%)为无非典型增生的增生性EP,5例(2.37%)为非典型增生性EP,2例(0.95%)为子宫内膜癌性EP。与患有EP及无非典型增生的增生性EP的患者(A组)相比,患有非典型增生性EP及癌性EP的患者(B组)年龄更大(p < 0.05),绝经后女性更常见(p < 0.05)且患有高血压的比例更高(p < 0.05),所有这些均具有统计学意义。

结论

根据我们的数据,子宫异常出血患者中子宫内膜息肉的患病率为21.95%。非典型增生和子宫内膜癌很少局限于息肉。年龄较大、绝经后状态和高血压可能会增加子宫内膜息肉发生癌前病变和恶性病变的风险。

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