Burkhard P R, Catalano Chiuvé S, Gronchi-Perrin A, Berney A, Vingerhoets F J G, Lüscher C
Service de neurologie, HUG, Faculté de médecine de Genève, 1211 Genève.
Rev Med Suisse. 2008 May 7;4(156):1145-8, 1150.
A variety of behavioral disorders occurring abruptly in patients with Parkinson's disease (PD) has been recently published and attracted considerable attention in the press. Taking the form of pathological gambling, compulsive shopping, addiction to Internet and to other recreational activities, hypersexuality or bulimia, impulse control disorders (ICD) related to PD are probably more frequent than previously appreciated and may have consequences as spectacular as disastrous for the involved patients. ICD are currently viewed as particular adverse reactions to antiparkinsonian medications, notably to dopamine agonists, and, accordingly, tend to improve or disappear when PD therapy is appropriately adjusted.
帕金森病(PD)患者中突然出现的多种行为障碍最近已被发表,并在媒体上引起了相当大的关注。与PD相关的冲动控制障碍(ICD)表现为病态赌博、强迫购物、网瘾及其他成瘾性娱乐活动、性欲亢进或暴食症,其发生率可能比之前认为的更高,对相关患者可能产生灾难性的严重后果。目前,ICD被视为抗帕金森病药物尤其是多巴胺激动剂的特殊不良反应,因此,当适当调整PD治疗方案时,ICD往往会改善或消失。