Loggie B, Ronan S G, Bean J, Das Gupta T K
Specialized Center for Cancer Research and Education, University of Illinois Medical Center, Chicago.
Arch Dermatol. 1991 Aug;127(8):1188-93.
Clinical and pathologic variables were compared between "older" (greater than or equal to 70 years) and "younger" (30 to 39 years) patients with primary invasive cutaneous melanoma. Older patients had more nodular melanomas and acral lentiginous melanomas (58%); superficial spreading melanomas predominated in younger patients (74%). Mean tumor thickness was greater in the older patients (3.95 vs 2.02 mm). Invasive levels 2 and 3 occurred more often in younger patients (41.1% vs 13%); level 5 occurred more often in older patients (30.4% vs 5.3%). Microscopic ulceration occurred more often in older (46.4%) than in younger patients (19.4%). Older patients classified as clinical stage I at presentation or with primary lesions 1.50- to 3.00-mm thick had poorer survival. Younger women survived longer than younger men; this was not true of older patients. The elderly patients with cutaneous melanoma were more likely to have poor prognostic features and thus more likely to die from melanoma than the younger patients.
对原发性浸润性皮肤黑色素瘤的“老年”（年龄大于或等于70岁）和“年轻”（30至39岁）患者的临床和病理变量进行了比较。老年患者的结节性黑色素瘤和肢端雀斑样痣黑色素瘤更多（58%）；年轻患者中浅表扩散性黑色素瘤占主导（74%）。老年患者的平均肿瘤厚度更大（3.95对2.02毫米）。年轻患者中侵袭水平2级和3级更为常见（41.1%对13%）；水平5级在老年患者中更为常见（30.4%对5.3%）。老年患者（46.4%）的显微镜下溃疡比年轻患者（19.4%）更常见。就诊时分类为临床I期或原发性病变厚度为1.50至3.00毫米的老年患者生存率较差。年轻女性比年轻男性存活时间更长；老年患者并非如此。与年轻患者相比，老年皮肤黑色素瘤患者更有可能具有不良预后特征，因此更有可能死于黑色素瘤。
