Takezawa Yusuke, Tanaka Kentaro, Yori Maiko, Tashiro Shohei, Shiro Motoo, Shionoya Mitsuhiko
Department of Chemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
J Org Chem. 2008 Aug 15;73(16):6092-8. doi: 10.1021/jo800587d. Epub 2008 Jul 17.
Metal-mediated base pairing with artificial ligand-bearing nucleosides allows site-selective metal incorporation inside DNA duplexes. In particular, this strategy has provided a general way of discrete, heterogeneous metal arrays in a programmable manner. To increase the kind of metallo-building blocks, we have newly synthesized two artificial nucleosides which have an O, S-donor ligand as the nucleobase moiety, mercaptopyridone ( M) and hydroxypyridinethione ( S). These nucleosides were found to efficiently form metal-mediated base pairs with soft transition metal ions such as Pd (2+) and Pt (2+).
金属介导的与带有人工配体的核苷的碱基配对能够使金属在DNA双链体内部进行位点选择性掺入。特别地，该策略提供了一种以可编程方式构建离散、异质金属阵列的通用方法。为了增加金属构建块的种类，我们新合成了两种人工核苷，它们具有O、S供体配体作为碱基部分，即巯基吡啶酮（M）和羟基吡啶硫酮（S）。发现这些核苷能与Pd(2+)和Pt(2+)等软过渡金属离子有效形成金属介导的碱基对。
