Haas Alex N, de Castro Gabriel D, Moreno Tatiana, Susin Cristiano, Albandar Jasim M, Oppermann Rui V, Rösing Cassiano K
Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
J Clin Periodontol. 2008 Aug;35(8):696-704. doi: 10.1111/j.1600-051X.2008.01254.x. Epub 2008 Jul 9.
To assess the effect of systemic azithromycin as a supplement to scaling and root planing (SRP) in the treatment of aggressive periodontitis (AgP).
Twenty-four individuals (13-26 years old) underwent a plaque control program, and then were treated with SRP. Subjects were assigned randomly into two groups; the test group used 500 mg azithromycin once a day for 3 days, whereas the control group used a placebo. Clinical variables were assessed at baseline, 3, 6, 9, and 12 months. The periodontal status at baseline and 12 months was compared using the Wald test, and adjusting for the effect of clustering of teeth within subjects.
There were no significant differences in visible plaque, gingival bleeding, and supragingival calculus between groups throughout the study. Periodontal probing depth (PPD) and clinical attachment level improved significantly from baseline to 12 months in both groups, with the test group showing significantly more reduction in mean PPD compared with controls (2.88 mm versus 1.85 mm, respectively, p=0.025). Subjects administering azithromycin showed a higher percentage of teeth with attachment gain >or=1 mm (81.34 versus 63.63, p=0.037), whereas the controls had higher percentage of teeth with attachment loss >or=1 mm (11.57 versus 2.24, p=0.015).
The adjunctive use of azithromycin has the potential to improve periodontal health of young patients with AgP.
评估全身应用阿奇霉素作为龈下刮治及根面平整术（SRP）辅助治疗侵袭性牙周炎（AgP）的效果。
24名年龄在13至26岁之间的个体接受了菌斑控制计划，随后接受SRP治疗。受试者被随机分为两组；试验组每天服用500毫克阿奇霉素，共3天，而对照组服用安慰剂。在基线、3、6、9和12个月时评估临床变量。使用Wald检验比较基线和12个月时的牙周状况，并对受试者牙齿聚集的影响进行校正。
在整个研究过程中，两组之间在可见菌斑、牙龈出血和龈上牙石方面没有显著差异。两组从基线到12个月时牙周探诊深度（PPD）和临床附着水平均有显著改善，试验组平均PPD的降低幅度明显大于对照组（分别为2.88毫米和1.85毫米，p = 0.025）。服用阿奇霉素的受试者附着增加≥1毫米的牙齿百分比更高（81.34对63.63，p = 0.037），而对照组附着丧失≥1毫米的牙齿百分比更高（11.57对2.24，p = 0.015）。
阿奇霉素辅助使用有可能改善年轻AgP患者的牙周健康。
