Korczyn Amos D
Sieratzki Chair of Neurology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Alzheimers Dement. 2008 May;4(3):176-8. doi: 10.1016/j.jalz.2007.11.008. Epub 2008 Apr 9.
The amyloid deposits in the brains of patients with Alzheimer's disease have attracted attention and are now considered not only an essential requirement for pathological diagnosis but also an important clue to the pathogenesis of the disease. This article looks critically at the basis of the "amyloid cascade hypothesis" to conclude that there are many issues that need to be resolved since they are inconsistent with the hypothesis.
阿尔茨海默病患者大脑中的淀粉样蛋白沉积已引起关注，目前不仅被视为病理诊断的必要条件，也是该疾病发病机制的重要线索。本文批判性地审视了“淀粉样蛋白级联假说”的基础，得出结论：由于存在许多与该假说不一致的问题，因此仍有许多问题需要解决。
