Hermanussen M, Tutkuviene J, Cesnys G, Lindeberg S, Kromeyer-Hauschild K, Stanley G, Godina E, Bogin B, Varela-Silva M I O, Finlayson G, Rühli F, Woitek U, Tresguerres J A F, Lieberman L S, Detel W
Medical Faculty, University of Vilnius, Lithuania.
Georgian Med News. 2008 Jun(159):34-9.
Overweight and obesity have developed into major illnesses in most Western societies and significantly contribute to the financial burden of modern public health systems. Almost daily, new therapeutic proposals are published in the lay press, and also the scientific literature has increased dramatically in recent years. E.g., when searching MEDLINE (1966 - May 2008 (1)), the key word "obesity" meanwhile appears in more than 108,000 articles. Primary focus however, is put upon aspects of treatment, neglecting the role of taste and appetite regulation. Combining keywords like "obesity + treatment" results in over 50.000 citations, "obesity + diet" in over 23.000, "obesity + energy + expenditure" in over 13.000 citations (even "obesity + gastric + bypass" still evoke 2.600 citations), whereas "obesity + appetite + regulation" result in some 3.000, "obesity + NPY" - neuropeptid Y being one of the major chemical stimulators of appetite - evoke some 500 and "obesity + Arc + nucleus" - the arcuate nucleus being the anatomical centre of appetite regulation - no more than 370 scientific publications. The apparent scarcity of literature about taste and appetite regulation and the amazing lack of interest in neuronal information processing in overweight and obesity, has prompted the authors to brainstorm new aspects of the world-wide derailment of weight control.
在大多数西方社会，超重和肥胖已发展成为主要疾病，并显著加重了现代公共卫生系统的经济负担。几乎每天，大众媒体都会刊登新的治疗建议，近年来科学文献的数量也急剧增加。例如，在检索MEDLINE（1966年至2008年5月（1））时，关键词“肥胖”目前出现在超过108,000篇文章中。然而，主要关注点在于治疗方面，而忽视了味觉和食欲调节的作用。将“肥胖 + 治疗”等关键词组合在一起，会得到超过50,000条引用，“肥胖 + 饮食”超过23,000条，“肥胖 + 能量 + 消耗”超过13,000条引用（甚至“肥胖 + 胃旁路手术”仍能引发2,600条引用），而“肥胖 + 食欲 + 调节”约为3,000条，“肥胖 + NPY”（神经肽Y是主要的食欲化学刺激物之一）约为500条，“肥胖 + 弓状核 + 核”（弓状核是食欲调节的解剖学中心）不超过370篇科学出版物。关于味觉和食欲调节的文献明显稀缺，以及对超重和肥胖中神经元信息处理惊人的缺乏关注，促使作者们思考全球体重控制失调的新方面。
